Search results for " computer model"
showing 2 items of 2 documents
Conformational response to ligand binding in phosphomannomutase2: insights into inborn glycosylation disorder.
2014
Background: Mutations in phosphomannomutase2 cause glycosylation disorder, a disease without a cure that will largely benefit from accurate ligand-bound models. Results: We obtained two models of phospomannomutase2 bound to glucose 1,6-bisphosphate and validated them with limited proteolysis. Conclusion: Ligand binding induces a large conformational transition in PMM2. Significance: We produce and validate closed-form models of PMM2 that represent a starting point for rational drug discovery.
Computer model and simulation of a traditional passive cooling ventilation system in a Modern building in Mazara del Vallo (Italy)
2008
Traditional and modern natural ventilation techniques have been integrated in a hybrid system for a retrofitting of public building in the city of Mazara del Vallo (Italy). The hybrid ventilation and air cooling system integrates a wind tower, an indirect evaporative heat exchanger, a ground cooling pipe network and ventilated façade. The first idea was to design a passive cooling system inspired to the typical wind towers of the Middle East, being the area very well ventilated. On the other hand, air humidity in summer is quite high and therefore the effectiveness of indirect evaporative cooling is quite low. For this reason, it was adopted a second passive cooling system consisting in a g…